To build a healthier America for all, we must confront the systems and policies that have resulted in the generational injustice that has given rise to health inequities. CDC’s Health Equity Guiding Principles for Inclusive Communication emphasize the importance of addressing all people inclusively and respectfully. These principles are intended to help public health professionals, particularly health communicators, within and outside of CDC ensure their communication products and strategies adapt to the specific cultural, linguistic, environmental, and historical situation of each population or audience of focus.