- Emphasizes comprehensive strategies that are based on human rights
- Divided into 10 sections with Annexes:
- International Legal Framework - including international instruments
- Problem Assessment and Strategy Development - including regional, national, and local strategies and inter-agency development
- Legislative Framework - including human rights and anti-trafficking legislation
- International Criminal Justice Cooperation
- Law Enforcement and Prosecution - including safety of victims during and after the prosecution and trial
- Victim Identification - including tips for health-care practitioners, ethical and safe conduct of interviews with victims, and victim certification
- Immigration Status of Victims and Their Repatriation and Resettlement - including repatriation of victims and protecting returnees and refugee victims of trafficking
- Victim Protection and Assistance - including access to information and legal representation, shelter programs, rehabilitation, skill training and education, and restitution and compensation for victims
- Prevention in Trafficking in Persons - including awareness-raising and eliminating gender-based discriminations and promoting women's economic rights
- Monitoring and Evaluation